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begin routers
...
autoreplay:
driver = accept
require_files = /etc/exim/autoreply/$domain/autoreply.${local_part}.msg
condition = ${if exists{/etc/exim/autoreply/$domain/autoreply.${local_part}.msg}{yes}{no}}
retry_use_local_part
transport = userautoreply
unseen

begin transports
...
userautoreply:
driver = autoreply
file = /etc/exim/autoreply/$domain/autoreply.${local_part}.msg
from = "${local_part}@${domain}"
subject = "${if def:h_Subject: {Autoreply: \"${rfc2047:$h_Subject:}\"} {Autoreply Message}}"
headers = Content-Type: text/plain; charset=utf-8;\nContent-Transfer-Encoding: 8bit
to = "${sender_address}"